The 20 Best Sandwich Restaurants in South Carolina

This small-town bakery and café specializes in rich cupcakes alongside a selection of sandwiches, paninis, and simple sides. Fresh ingredients and thoughtfully prepared box lunches make it a convenient stop for a casual meal. Attentive, welcoming staff contribute to a comfortable, neighborly atmosphere.

Cribb's Sandwich and Sweet Shop is a cozy downtown deli known for generously filled sandwiches, fresh salads, and comforting soups. Guests highlight the homemade sides and daily baked cakes and desserts. The welcoming staff and intimate, small-town atmosphere create an easygoing spot for a satisfying lunch or a sweet treat.

Alvin Ords of Bluffton is a classic sandwich shop known for hearty, made-to-order subs and hot sandwiches. Favorites include the muffaletta with its housemade olive mixture and the aptly named Salvation sandwich. Guests describe the setting as an old-school spot with personable, welcoming staff, plus simple extras like cookies and salads.

Immaculate Consumption is a bustling downtown café known for its house-roasted coffee and freshly prepared sandwiches, salads, and soups. Guests highlight flavorful combinations on sourdough bread, refreshing lemonade, and tempting baked goods. The welcoming staff and relaxed, social setting make it a comfortable spot to linger near the capitol area.

The Southern General specializes in hearty sandwiches and wraps with a Southern-inspired twist, complemented by crisp fries and house-made sauces. Guests highlight flavorful options like smoked onion dip, pork sandwiches with pimento cheese, and indulgent desserts. Service is described as friendly and efficient, making it a popular choice for both dine-in meals and takeout.

Alvin Ord's Sandwich Shop is a locally owned sandwich spot known for its generous portions and creative menu. Fresh, dense bread and warm, well-balanced fillings give the sandwiches a satisfying, homemade feel. The retro-inspired interior adds character to the casual dining experience, and lines at lunch reflect its strong local following.

Two Chefs Eastside offers a casual counter-service experience with a focus on sandwiches, salads, and prepared cold items. Guests choose at the counter, serve their own drinks, and have dishes brought to the table. A changing selection of salads and sides highlights fresh ingredients and varied flavors, while occasional special dinners feature thoughtfully composed mains and seasonal accompaniments.

The Deli at Pelham Falls serves classic deli favorites, from hot Philly cheesesteaks and Italian subs to burgers and tuna salad sandwiches. Guests appreciate the fresh ingredients, flavorful soups, and side options such as Greek pasta salad and coleslaw. The casual, bustling setting and attentive, good-natured staff create a comfortable spot for a satisfying meal.

Triangle Subs & Cafe is a casual spot known for generously filled subs and substantial portions. Breakfast and brunch feature fluffy three-egg omelets with varied fillings, crisp rustic home fries, and classic sides like pancakes. Guests appreciate the well-prepared coffee and attentive service that round out the relaxed café experience.

Midtown Deli offers a broad selection of sandwiches, salads, soups, and baked potatoes in a relaxed, counter-service environment. Generous portions, fresh bread, and housemade potato chips stand out in many orders. Guests appreciate the variety, from classic deli combinations to hot sandwiches, along with freshly brewed iced tea served sweet or unsweetened.

Firehouse Subs serves hearty hot sandwiches with fresh-tasting ingredients and soft, well-prepared bread. Guests mention satisfying sides such as cookies and macaroni and cheese, with orders typically served hot and promptly. The atmosphere is casual and busy, with staff described as welcoming. The brand’s support of first responders adds a distinctive character to the dining experience.